Synthesis and study of biological activity of tetrahydro-1H-[3]-benzazepines

The 3-Benzazepines are an important class of compounds in drug discovery due to their biological activity such as analgesic, antihypertensive or anticancer properties as well as dopaminergic or antidopaminergic activity. In particular, the tetrahydro-1H-[3]- benzazepine is a common skeleton in a number of natural and pharmaceutical products. As consequence of the interesting biological properties, derivatives of the tetrahydro-1H-[3]-benzazepines, especially the 1-aryl substituted have been synthesized by different routes and evaluated their pharmacologic activity. [1,2] The stereoselective synthetic approaches of tetrahydro-1H-[3]-benzazepine have focused on ring enlargements, as the Stevens rearrangement (SR) which is a good regio- and diastereoselective synthetic methodology. In my research group, the reaction conditions to synthesize tetrahydro-1H-[3]-benzazepines 1,2-disubstituted by via SR from tetrahydroisoquinolinium salts conveniently functionalized have been optimized. [3,4] This methodology allowed us to obtain a wide variety of tetrahydro-1H-[3]- benzazepines 1,2-disubstituted with different substituents at A-ring (Cl, OMe) and the C-1 (-C6H4X, X = H, OMe, Cl, NO2, NMe2, NH2, SMe) and C-2 (Electron-withdrawing groups) positions. The demethylation of the synthesized tetrahydroisoquinolines and tetrahydro-1H-[3]-benzazepines 1,2-disubstituted, lead us to get catechol structure, an important requirement for their dopaminergic activity. We have studied the dopaminergic activity of the synthesized compounds by radioligand binding assays, establishing a structure-activity relationships. Literature: [1] A. Gini, Adv. Synth. Catal. 2016, 358, 4049. [2] H. Damsen, Eur. J. Org. Chem. 2015, 36, 7880. [3] M. Valpuesta, Eur. J. Org. Chem. 2010, 23, 4393. [4] M. Ariza, Eur. J. Org. Chem. 2011, 32, 6507.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Synthesis of bioactive compounds. Studies of their attachment to nanoparticles

The 1-aryl tetrahydroisoquinolines have attracted great attention in medicinal chemistry due to their biological activity. These compounds present antitumor, anti-HIV and antibacterial activities. Several analogues of 1-aryl tetrahydroisoquinoline are used for the treatment of neurodegenerative diseases such as Parkinson´s and Alzheimer´s diseases since also act as dopaminergic antagonists and N-methyl-D-aspartate receptor antagonist. [1] The 1-substituted tetrahydro-3-benzazepines have also been studied for their affinity to the Phencylclidine binding site of the NMDA receptor as well as for their affinity to the dopaminergic receptors. [2] In the last years, various methods have been carried out to satisfy the demand of novel tetrahydroisoquinolines and tetrahydro-3-benzazepines. We have synthesized nor-1-aryl tetrahydroisoquinolines with different substituents in the aryl group of C-1 (H, NMe2, SMe, NO2, NH2). In addition to this, we have performed the synthesis of nor-tetrahydro-3-benzazepinas by different routes, obtaining the best results via opening of epoxides by arylphenethylamines and subsequent cyclization. The nor-tetrahydroisoquinolines and nor-tetrahydro-3-benzazepines have been derivatized to obtain appropiate adsorbates which can be attached to nanoparticles. This fact is crutial in drug delivery systems as well as in the improvement of the biocompatibility of these compounds. Literature: [1] Toshiaki Saitoh, Eur. J. Med. Chem. 2006, 41, 241. Mattias Ludwig, Eur. J. Med. 2006, 41, 1003. [2] Olaf Krull, Bioorg. Med. Chem. 2004, 12, 1439.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Les cuines del món

Treball de l'alumnat del Grau d'Educació Primària de la Facultat d'Educació de la UB. Proposta d'activitat emmarcada al projecte de recerca EDU201S-69332-R "Desarrollo de las competencias para la educación multilingüe". Any: 2017. Tutors: Juli Palou i Margarida CambraMitjançant aquesta proposta, intentem tractar la interculturalitat i la diversitat de llengües que hi ha a la classe. A partir d’una activitat culinària, pretenem que el conjunt de nens i nenes comparteixin els plats més típics del seu país d’origen, per fomentar la incorporació dels alumnes i les seves cultures pertinents

Job satisfaction and its influence on the organizational commitment of the employees in the Ecuadorian hotel industry (Quito, Guayaquil, Cuenca)

La satisfacción laboral cumple un papel fundamental dentro de las empresas hoteleras. Considerando esta premisa, este trabajo de tesis doctoral pretende medir y evaluar la satisfacción laboral y el clima organizacional que se genera en el trabajador del sector de alojamiento en las tres ciudades más importantes del Ecuador: Guayaquil, Quito y Cuenca. Para el desarrollo del estudio se aplicó una metodología de tipo cuantitativo, el cual se llevó a cabo mediante una investigación de campo con base en 920 encuestas validadas y aplicadas a empleados del sector hotelero de las tres principales ciudades del Ecuador. El cuestionario incluyó preguntas sobre satisfacción laboral y el clima organizacional. El procesamiento de datos supuso la revisión de las encuestas levantadas, seguidamente de la clasificación y codificación de la información, y luego se elaboró el modelamiento de la base de datos en el programa SPSS. Los resultados obtenidos determinaron que el sector hotelero ecuatoriano debe enfocarse en crear estrategias, políticas y escenarios que incentiven el compromiso afectivo en los trabajadores para una mayor calidad en el servicio brindado y diligencia en el desempeño de su trabajo.The labor satisfaction plays a fundamental role within the hotel companies, this doctoral thesis work tries to measure and to evaluate the labor satisfaction and the organizacional climate that is generated in the worker of the sector of lodging in the three important cities but of Ecuador, which are: Guayaquil, Quito and Cuenca. For the development of this study I am applied a methodology of quantitative type since sis data are quantified, which I take I finish by means of an investigation of field on the basis of 920 validated surveys, made employees of the hotel sector of the three main cities of Ecuador, I am applied a questionnaire which includes questions of labor satisfaction as well as questions related to the organizacional climate, it was come to revisón of the raised surveys, next of the classification and codification, and soon the modelamiento of the data base in program SPSS was elaborated. The obtained results determine a challenge for the Ecuadorian hotel sector, in as much must focus in creating strategies, policies and scenes that stimulate the affective commitment in the workers, for a greater quality in the offered service and hastens in the performance of their work

Profiling of Airbnb\u27s activities in Ecuador\u27s main cities

Airbnb in Ecuador is a platform offering since 2008 a new lodging concept that best can be described as a sharing economy model through the rental of private rooms and apartments. The article provides an overview of Airbnb\u27s activities in Ecuador, more in particular in 22 cities, respectively the capitals of 22 provinces, using the 16 metrics available on the platform of AirDNA. Factor analysis was applied to reduce the number of variables to three main surrogate variables (lodging typology, prices and rates, market metrics) that characterizes Airbnb and retains the original factor variability. Additionally, based on the occupation frequency of Airbnb\u27s rental places the cluster analysis permitted to group the cities in which Airbnb is active on the basis of the following indicators: amazon destinations, traditions, sun and beach, nature culture and events, and the country\u27s capital. The research provided a clear image of Airbnb\u27s approach and impact on the formal accommodation sector, which ultimately will enable the sector to come up with innovative products to compete more efficiently Airbnb\u27s market range

Study and characterization of modified silicon surfaces with organic molecules

Nanostructured thin films and subsequent biofunctionalization of silicon substrates are essential for the development of biosensors devices. The formation of organic monolayers on silicon substrates via Si-C bound allows specific interactions with biomolecules and presents several advantages like greater detection sensitivity and stability against hydrolytic cleavage.1 In this sense, to control the orientation and spacing between grafted functional moieties on the surface, tripodal oligo (p-phenylene)s have become ideal anisotropic adsorbates due to their shape-persistent and selfstanding characteristics.2 On the other hand, biomolecules such as tehtahydro[3]benzazepines are well-known to contain in their structure a phenetylamine skeleton, which is also present in dopaminergic receptors and drugs, therefore these molecules have a remarkable interest in medicinal chemistry. Here we report the synthesis and characterization of several tetrahydro[3]benzazepines and tripod-shaped oligo(p-phenylene)s which were suitably functionalized for its subsequent adsorption on silicon surfaces by hydrosilylation and/or CuAAc click reaction. X-ray photoemission spectroscopy (XPS) and atomic force microscopy (AFM) analysis were also carried out to reveal the presence of the grafted molecules on the different Si surfaces.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Promoting Sustainable and Resilient Constructive Patterns in Vulnerable Communities: Habitat for Humanity’s Sustainable Housing Prototypes in El Salvador

The global challenges regarding sustainability and the guarantee of minimum habitability requirements have led to the transformation of construction practices, where research has failed to achieve sufficient dissemination and findings. The purpose of this research is to promote sustainable and resilient patterns in construction in vulnerable neighbourhoods in emerging countries by disseminating techniques and mechanisms through in situ transfer workshops and by raising awareness of the environmental importance of construction. Regarding materials and methods, this paper contributes innovative insights by combining training workshops and awareness-raising sessions to promote both environmental education and sustainable and optimised habits in construction. These methods are applied and tested in a real case study in El Salvador. Subsequent to carrying out a multi-disciplinary assessment analysis, the outcomes and results have led to the design of prototypes that have obtained a global EDGE certificate on sustainable construction and efficient use of resources once the users’ testimonies, weaknesses, and strengths have been addressed. The conclusions indicate that families, volunteers, and technical workers need to be trained by promoting environmental awareness in social housing and establishing a plan for dissemination to communicate across universities and public and private institutions in order to replicate guidelines across American dry-corridor countries.University of Seville US-AYP/18/2022 US-2020UI003 US-d07/201

Human resource management and environment management systems: an empirical study

The present study focuses on understanding and measuring the effect that the implementation of an ISO 14001 environmental management system (EMS) has on human resource (HR) management in a company. The paper proposes and applies a measurement instrument to test the hypotheses derived from the theoretical framework established by Daily & Huang (2001) as well as from the ISO 14001 standards. Data collection was carried out by mailing a survey to the person responsible for environmental affairs of businesses with an ISO 14001 EMS implemented, or in the advanced stages of being implemented, in one autonomous region of Spain. Both reliability analysis and factor analysis, if necessary, were performed for the scales used. The results obtained indicate that the HR factors act as predicted by the hypotheses, except in the case of rewards. Finally, the present study provides empirical evidence in order to test and extend the model proposed by Daily & Huang